Humasis

HUBI Troponin I is one step in vitro diagnostic test based on immunochromatography. It must be used with HUBI-QUAN pro and designed for quantitative determination of cardiac Troponin I in human whole blood or plasma. The Troponin complex, located on the myosin filament of the actinomyosin contractile apparatus of muscle. Troponin complex consist of Troponin T, which binds the Troponin complex to the tropomyosin strand, Troponin C, which binds calcium and regulates contraction, Troponin I, which inhibits myosin ATPase activity. There is one cardiac specific isoform of cTnl, with a molecular weight of 26.5kDa, cTnl becomes elevated 4~9 hours following an acute myocardial infarction (AMI) and remains elevated for about 6-10 days. Concentrations can increase 10~1000 times the upper limit of values founded in normal healthy subjects. Smaller increases may be found in patients presenting with unstable angina, sepsis, pericarditis, injury due to trauma etc. TnT is a 39kDa protein. There are a number of cardiac isomers of TnT which have 40~45% dissimilarity with skeletal muscle TnT. 6~8% of cardiac TnT (cTnT) is found in the cytoplasm and the remainder is found complexed in tropomyosin, cTnT becomes elevated 4~9 hours following an acute myocardial infarction (AMI) and remains elevated for about 8 days. Levels may increase more than 100 times the upper limit of values found in normal healthy subjects. Smaller increases may be found in patients presenting with unstable angina.