Humasis

The HUBI D-Dimer is a rapid, point of care test based on immunochromatography assay to be used with the HUBI-QUAN pro for the quantitative determination of cross-linked fibrin degradation products (D-Dimers) in citrate or EDTA anticoagulated whole blood or plasma specimens.

Fibrinogen is a main protein of the blood coagulation system. During the coagulation process, thrombin converts fibrinogen to soluble fibrin by the proteolytic removal of both fibrinopeptide A and B. The fibrin clot is then digested by plasmin and fibrin degradation products with different molecular weights are released into the bloodstream. D-dimer is a final product of fibrin degradation (MW 180 kDa). It consists of the remnants of all three chains that are cross linked by disulfide bonds. The dimeric structure is held by two isopeptide bonds between the C-terminal parts of g-chains forming a cross-linked region. Elevated levels of D-dimer were found in the blood of patients with pulmonary thromboembolism, deep vein thrombosis (DVT), atherosclerosis and other cardiovascular diseases.